反应详情

温度

60 °C

A solution of 5-fluoro-indolyl-3-propylbromide (10.67 g, 41 mmol) and sodium azide (3.9 g, 60 mmol) in anhydrous N,N-dimethylformamide (60 ml) was allowed to stir at 60° C. for 18 hours. The mixture was poured into water (150 ml), extracted with methylene chloride (3×150 ml), washed with water (3×100 ml). The organic layer was dried over sodium sulfate, filtered and the solvent was removed under vacuurml Chromatography (30% ethyl acetate-hexanes) afforded 8.10 g (89%) of product as a clear oil.

1. extractionextracted with methylene chloride (3×150 ml)
2. washwashed with water (3×100 ml)
3. dry with materialThe organic layer was dried over sodium sulfate
4. filtrationfiltered
5. customthe solvent was removed under vacuurml Chromatography (30% ethyl acetate-hexanes)