反应详情

温度

90 °C

A solution of 2-(6-fluorochroman-8-yloxy)ethylchloride (0.41 g, 2.2 mmol), 3-(2-bromoethyl)indole (0.25 g, 1.1 mmol) and triethylamine (0.23 g, 2.2 mmol) in anhydrous dimethylsulfoxide (20 ml) was allowed to stir for 12 hours at 90° C. The mixture was poured into water (100 ml) and extracted with methylene chloride (3×100 ml). The organic layer was washed with water (3×150 ml), dried over anhydrous sodium sulfate, filtered and the solvent was removed under vacuum. Chromatography (10% methanol-methylene choride plus ammonium hydroxide) afforded 0.15 g (34%) of product as a yellow oil.

1. extractionextracted with methylene chloride (3×100 ml)
2. washThe organic layer was washed with water (3×150 ml)
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationfiltered
5. customthe solvent was removed under vacuum