Potassium Carbonate → 1-Ethynyl-4-(1-methoxycyclopropyl)-benzene

HRID 1596929Notes

Reaction equation

HRID 1596929 reaction equation
[CH3:1][O:2][C:3]1([C:6]2[CH:11]=[CH:10][C:9]([C:12]#[C:13][Si](C)(C)C)=[CH:8][CH:7]=2)[CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:12]([C:9]1[CH:10]=[CH:11][C:6]([C:3]2([O:2][CH3:1])[CH2:4][CH2:5]2)=[CH:7][CH:8]=1)#[CH:13]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568890[4-(1-Methoxycyclopropyl)phenylethynyl]-trimethylsilane2×

Product 1

HCID 225689501-Ethynyl-4-(1-methoxycyclopropyl)-benzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-methoxycyclopropyl)-phenylethynyl]-trimethylsilane (Intermediate 60, 285.0 mg, 1.18 mmols) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (220 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-27097d9257a14763a83c288928d746fd
Source dataset
uspto-grants-2001_09
Patent number
US06291677B1

Reaction notes

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