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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1597150Generated: October 30, 2026

Acetic Acid → HCID 21699317, compound

https://huagongshe.com/reaction/1597150

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantPyrrolidineHCID 31268—
Reactant6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedioneHCID 73273—
SolventWaterHCID 962—
ProductHCID 21699317HCID 2169931729%

Reaction Steps

To a solution of 1.78 g of pyrrolidine in water (20 ml), 1.33 g of 6-chloromethyluracil were added. The resulting mixture was stirred at room temperature for 24 hours and neutralized with acetic acid. The reaction mixture was then concentrated under reduced pressure. The residue so obtained was washed with methanol and then filtered, whereby 466 mg of the title compound were obtained (yield: 29%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06294535B1
Source datasetuspto-grants-2001_09
ORD IDord-fa0aa13a6be843ebae8846447fd55b9f
Source noteuspto-grants-2001_09