HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 21699317, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione | HCID 73273 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 21699317 | HCID 21699317 | 29% |
Reaction Steps
To a solution of 1.78 g of pyrrolidine in water (20 ml), 1.33 g of 6-chloromethyluracil were added. The resulting mixture was stirred at room temperature for 24 hours and neutralized with acetic acid. The reaction mixture was then concentrated under reduced pressure. The residue so obtained was washed with methanol and then filtered, whereby 466 mg of the title compound were obtained (yield: 29%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294535B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-fa0aa13a6be843ebae8846447fd55b9f |
| Source note | uspto-grants-2001_09 |