Acetic Acid → HCID 21699317, compound

HRID 1597150Notes

Reaction equation

HRID 1597150 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:7][C:8]1[NH:13][C:12](=[O:14])[NH:11][C:10](=[O:15])[CH:9]=1.C(O)(=O)C>O>[N:1]1([CH2:7][C:8]2[NH:13][C:12](=[O:14])[NH:11][C:10](=[O:15])[CH:9]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 31268PyrrolidineHCID 732736-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 21699317HCID 21699317, compoundYield 29%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 1.78 g of pyrrolidine in water (20 ml), 1.33 g of 6-chloromethyluracil were added. The resulting mixture was stirred at room temperature for 24 hours and neutralized with acetic acid. The reaction mixture was then concentrated under reduced pressure. The residue so obtained was washed with methanol and then filtered, whereby 466 mg of the title compound were obtained (yield: 29%).

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. customThe residue so obtained
  3. washwas washed with methanol
  4. filtrationfiltered

Sources & evidence

ORD record
ord-fa0aa13a6be843ebae8846447fd55b9f
Source dataset
uspto-grants-2001_09
Patent number
US06294535B1

Reaction notes

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