反应详情

温度

50 °C

Next, 150 mg of the N-cyano-N′-(5-chlorouracil-6-ylmethyl)-S-methylisothiourea were suspended in ethanol (3 ml), followed by the addition of 2 ml of a 30% solution of methylamine in ethanol. The resulting mixture was heated at 50° C. for 3.5 hours under stirring. After an insoluble matter was filtered off, the filtrate was allowed to cool back to room temperature. A precipitate from the filtrate was collected by filtration, whereby 12 mg of the title compound were obtained (yield: 96%).

1. filtrationAfter an insoluble matter was filtered off
2. temperatureto cool back to room temperature
3. filtrationA precipitate from the filtrate was collected by filtration