Methylamine → HCID 178484943, compound

HRID 1597159Notes

Reaction equation

HRID 1597159 reaction equation
[C:1]([NH:3][C:4](=[N:7][CH2:8][C:9]1[NH:14][C:13](=[O:15])[NH:12][C:11](=[O:16])[C:10]=1[Cl:17])SC)#[N:2].[CH3:18][NH2:19]>C(O)C>[C:1]([NH:3][C:4]([NH:19][CH3:18])=[N:7][CH2:8][C:9]1[NH:14][C:13](=[O:15])[NH:12][C:11](=[O:16])[C:10]=1[Cl:17])#[N:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 21699306N-cyano-N'-(5-chlorouracil-6-ylmethyl)-S-methylisothiourea

Product 1

HCID 178484943HCID 178484943, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
50 °C

Procedure

Next, 150 mg of the N-cyano-N′-(5-chlorouracil-6-ylmethyl)-S-methylisothiourea were suspended in ethanol (3 ml), followed by the addition of 2 ml of a 30% solution of methylamine in ethanol. The resulting mixture was heated at 50° C. for 3.5 hours under stirring. After an insoluble matter was filtered off, the filtrate was allowed to cool back to room temperature. A precipitate from the filtrate was collected by filtration, whereby 12 mg of the title compound were obtained (yield: 96%).

Workup

  1. filtrationAfter an insoluble matter was filtered off
  2. temperatureto cool back to room temperature
  3. filtrationA precipitate from the filtrate was collected by filtration

Sources & evidence

ORD record
ord-661beb147d114b4f8a1275cf852a6d40
Source dataset
uspto-grants-2001_09
Patent number
US06294535B1

Reaction notes

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