2-Naphthoyl chloride → HCID 15538692, compound

HRID 1597182Notes

Reaction equation

HRID 1597182 reaction equation
[NH2:1][C:2]1[C:7]2[NH:8][C:9](=[O:12])[CH2:10][O:11][C:6]=2[CH:5]=[C:4]([F:13])[C:3]=1[N:14]1[C:19](=[O:20])[CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[N:16]([CH3:25])[C:15]1=[O:26].[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][C:28]=1[C:37](Cl)=[O:38]>O1CCOCC1>[CH:27]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH:30]=[CH:29][C:28]=1[C:37]([NH:1][C:2]1[C:7]2[NH:8][C:9](=[O:12])[CH2:10][O:11][C:6]=2[CH:5]=[C:4]([F:13])[C:3]=1[N:14]1[C:19](=[O:20])[CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[N:16]([CH3:25])[C:15]1=[O:26])=[O:38]

Participants

4

Reactant 2

HCID 752462-Naphthoyl chlorideHCID 23502535HCID 23502535, compound

Product 1

HCID 15538692HCID 15538692, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-[5-Amino-7-fluoro-2H-1,4-benzoxazine-3(4H)-on-6-yl]-1-methyl-6-trifluoromethyl-2,4-(1H, 3H)-pyrimidinedione (0.37 g) and 2-naphthoyl chloride (0.21 g) were mixed in dioxane (15 ml) and the mixture was refluxed for 6 hr. After evaporation of solvent, the residue was recrystallized from toluene (0.20 g).

Workup

  1. temperaturethe mixture was refluxed for 6 hr
  2. customAfter evaporation of solvent
  3. customthe residue was recrystallized from toluene (0.20 g)

Sources & evidence

ORD record
ord-0d8f7886bc0546399b7ea3a0ee47fe1a
Source dataset
uspto-grants-2001_09
Patent number
US06294503B1

Reaction notes

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