Hydrochloric Acid → HCID 86757427, compound

HRID 1597190Notes

Reaction equation

HRID 1597190 reaction equation
[ClH:1].[CH3:2][O:3][C@H:4]([CH3:7])[C:5]#[N:6].[CH2:8]([OH:10])[CH3:9]>>[ClH:1].[CH2:8]([O:10][C:5](=[NH:6])[C@H:4]([O:3][CH3:2])[CH3:7])[CH3:9]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 5702569(2R)-2-Methoxypropanenitrile

Product 1

HCID 86757427HCID 86757427, compoundYield 100%

Procedure

Hydrogen chloride gas was passed into an icecold solution of (R)-2-methoxy-propionitrile (prepared according to the method of Example 1, Step A, 9.91 g, 116.5 mmol) in anhydrous ethanol (100 mL) until the solution was saturated with the gas. The reaction was stored in a refrigerator over night. The excess ethanol was removed under vacuum to obtain the title compound of Example 1, Step B as a deliquescent solid (19.5 g, 100% yield); [α]D+46.4 (c=1, methanol); 1H NMR (CDCl3, 300 MHz) δ1.4 (d, 3H), 3.4 (s, 1H), 3.7 (q, 2H), 4.8 (q, 1H), 6.2 (b, 1H).

Workup

  1. customprepared
  2. waitThe reaction was stored in a refrigerator over night
  3. customThe excess ethanol was removed under vacuum

Sources & evidence

ORD record
ord-c4134005cf694601a3ff4169e29a63ed
Source dataset
uspto-grants-2001_09
Patent number
US06294538B1

Reaction notes

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