反应详情

A solution of (RS)-lactonitrile (378 9, 5.32 mol) in ethyl ether (1.46 L) and ethanol (0.34 L) was saturated with hydrogen chloride gas at 0° C.-5° C. for 0.5 h and kept at 5° C. for 60 h. The solid was filtered off and washed twice with ethyl ether to give 2-hydroxypropionimidic acid ethyl ester hydrochloride as a solid (815 g, 99%); mp, 165-168° C.; 1H NMR (DMSO-d6, 300 MHz) δ1.38 (t, 3H), 4.49(q, 1H), 6.55-7.11 (bs, 1H).

1. filtrationThe solid was filtered off
2. washwashed twice with ethyl ether