Benzaldehyde → HCID 73824710, compound

HRID 1597196Notes

Reaction equation

[NH2:1][C:2]1[CH:24]=[C:23]([Cl:25])[C:5]([CH2:6][C:7]2[CH:22]=[CH:21][C:10]([C:11]([C:13]3[CH:14]=[C:15]([Cl:20])[C:16]([Cl:19])=[N:17][CH:18]=3)=[O:12])=[CH:9][CH:8]=2)=[C:4]([Cl:26])[CH:3]=1.[N:27]([O-])=O.[Na+].Cl[Sn]Cl.[CH:34](=O)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[CH:34](=[N:27][NH:1][C:2]1[CH:24]=[C:23]([Cl:25])[C:5]([CH2:6][C:7]2[CH:8]=[CH:9][C:10]([C:11](=[O:12])[C:13]3[CH:14]=[C:15]([Cl:20])[C:16]([Cl:19])=[N:17][CH:18]=3)=[CH:21][CH:22]=2)=[C:4]([Cl:26])[CH:3]=1)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1

Participants

Reactant 4

HCID 240Benzaldehyde

HCID 24479Stannous Chloride

HCID 21699354HCID 21699354, compound

HCID 23668193Sodium Nitrite

Product 1

HCID 73824710HCID 73824710, compoundYield 98.2%

Procedure

The title compound was prepared as yellow crystals at yield of 98.2%, in a similar manner as in Reference Example 13, by the reaction of 5-[4-(4-amino-2,6-dichlorobenzyl)benzoyl]-2,3-dichloropyridine, NaNO2, SnCl2 and benzaldehyde.

Sources & evidence

ORD record: ord-1e8b6956859e4850aadabce38af26cc0
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06294536B1

Reaction notes

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