Benzaldehyde → HCID 70251186, compound

HRID 1597198Notes

Reaction equation

[NH2:1][C:2]1[CH:23]=[C:22]([Cl:24])[C:5]([CH2:6][C:7]2[CH:21]=[CH:20][C:10]([C:11]([C:13]3[CH:14]=[CH:15][C:16]([CH3:19])=[N:17][CH:18]=3)=[O:12])=[CH:9][CH:8]=2)=[C:4]([Cl:25])[CH:3]=1.[N:26]([O-])=O.[Na+].Cl[Sn]Cl.[CH:33](=O)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH:33](=[N:26][NH:1][C:2]1[CH:23]=[C:22]([Cl:24])[C:5]([CH2:6][C:7]2[CH:21]=[CH:20][C:10]([C:11](=[O:12])[C:13]3[CH:14]=[CH:15][C:16]([CH3:19])=[N:17][CH:18]=3)=[CH:9][CH:8]=2)=[C:4]([Cl:25])[CH:3]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

Reactant 4

HCID 240Benzaldehyde

HCID 24479Stannous Chloride

HCID 21699347HCID 21699347, compound

HCID 23668193Sodium Nitrite

Product 1

HCID 70251186HCID 70251186, compoundYield 92%

Procedure

The title compound was prepared as pale yellow crystals at yield of 92.0%, in a similar manner as in Reference Example 13, by the reaction of 5-[4-(4-amino-2,6-dichlorobenzyl)benzoyl]-2-methylpyridine, NaNO2, SnCl2 and benzaldehyde.

Sources & evidence

ORD record: ord-c8adb7a9bed54f32a1e0bca2984a8cb2
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06294536B1

Reaction notes

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