反应详情

A solution of 7-benzyloxy4-methylsulphanylquinazoline (3 g, 10.6 mmol) in TFA (30 ml) was heated at reflux for 5 hours. After cooling, the volatiles were removed by evaporation. The residue was suspended in water and solid sodium hydrogen carbonate was added until complete dissolution. After extraction with ether, the aqueous layer was acidified to pH2 with 2M hydrochloric acid. The precipitate was collected by filtration, washed with water, followed by ether and dried under vacuum to give 7-hydroxy4-methylsulphanylquinazoline (2 g, quant.).

1. temperatureat reflux for 5 hours
2. temperatureAfter cooling
3. customthe volatiles were removed by evaporation
4. additionsolid sodium hydrogen carbonate was added until complete dissolution
5. extractionAfter extraction with ether
6. filtrationThe precipitate was collected by filtration
7. washwashed with water
8. customdried under vacuum