反应详情

A solution of 7-benzyloxy-4-(2-methoxyethylsulphanyl)quinazoline (8 g, 24.5 mmol) in TFA (80 ml) was refluxed for 5 hours. After cooling and removal of the volatiles by evaporation, the residue was triturated with water, collected by filtration, washed with water and then ethyl acetate. The residue was resuspended in methylene chloride, filtered, washed with petroleum ether and dried under vacuum to give 7-hydroxy-4-(2-methoxyethylsulphanyl)quinazoline (5.8 g, quant.).

1. temperatureAfter cooling
2. customremoval of the volatiles
3. customby evaporation
4. customthe residue was triturated with water
5. filtrationcollected by filtration
6. washwashed with water
7. filtrationfiltered
8. washwashed with petroleum ether
9. customdried under vacuum