反应详情

Using a procedure analogous to the one described for the synthesis of the starting material in Example 16, 4-morpholinobut-2-en-1-ol (1.27 g, 8.13 mmol), (J. Med. Chem. 1972, 15, 110-112), was reacted with 7-hydroxy-4-methylsulphanylquinazoline (1.2 g, 6.25 mmol), (prepared as described for the starting material in Example 8), in methylene chloride (30 ml) in the presence of triphenylphosphine (4.09 g, 1.56 mmol) and diethyl azodicarboxylate (2.46 ml, 1.56 mmol) to give 4-methylsulphanyl-7-(4-morpholinobut-2-en-1-yloxy)quinazoline (1.15 g, 55%).

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