反应详情

A solution of 5 g of 4-acetamido-1-benzyl-4-phenylpiperidine in 50 ml of THF is added to a suspension of 1.5 g of lithium aluminum hydride in 20 ml of THF and the mixture is refluxed for 3 hours. After cooling, a solution of 1 ml of concentrated NaOH in 8 ml of water is added, the inorganic salts are filtered and the filtrate is evaporated under vacuum. The oil obtained is dissolved in 50 ml of THF, this solution is added to a suspension of 1.5 ml of lithium aluminum hydride in 20 ml of THF and the mixture is refluxed for 1 hour. The reaction mixture is hydrolyzed by addition of a solution of 0.5 ml of concentrated NaOH in 6 ml of water, the inorganic salts filtered and the filtrate evaporated under vacuum. 4.8 g of the expected product are obtained, which product is used as it is in the next stage.

1. temperaturethe mixture is refluxed for 3 hours
2. temperatureAfter cooling
3. filtrationthe inorganic salts are filtered
4. customthe filtrate is evaporated under vacuum
5. customThe oil obtained
6. temperaturethe mixture is refluxed for 1 hour
7. filtrationthe inorganic salts filtered
8. customthe filtrate evaporated under vacuum