反应详情

Platinum oxide (850 mg) was added to a solution of 2-benzyl-1,2,3,4-tetrahydrobenzo[b][1,6]-naphthyridine (8.5 g, 31 mmol) in trifluoroacetic acid (155 ml), and catalytic reduction was carried out at 50° C. for 24 hours. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was made basic with 6N sodium hydroxide and extracted with toluene. The extract solution was dried over anhydrous sodium sulfate, and the organic solvent was removed by concentration under reduced pressure and the residue was recrystallized from isopropyl ether to obtain the desired compound (5.3 g, 90%) as white crystals.

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. extractionextracted with toluene
4. dry with materialThe extract solution was dried over anhydrous sodium sulfate
5. customthe organic solvent was removed by concentration under reduced pressure
6. customthe residue was recrystallized from isopropyl ether