Hydrochloric Acid → 4-Amino-1-(1-benzyloxycarbonyl-4-piperidinylmethyl)piperidine

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Reaction Steps

To a solution of 1-(1-benzyloxycarbonyl-4-piperidinylmethyl)-4-(t-butoxycarbonylamino)piperidine (7.77 g) in ethanol (30 ml) is added a 30% solution of hydrochloric acid in ethanol (15 ml) under ice-cooling, and the mixture is stirred at room temperature for 5 hours. The solvent is evaporated under reduced pressure, and the residue is dissolved in water. The solution is basified with potassium carbonate and extracted with chloroform. The extract is washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent is evaporated under reduced pressure to give the desired compound (6.04 g) as an oily product.

Provenance & Evidence