反应详情

To a solution of 1-(1-benzyloxycarbonyl-4-piperidinylmethyl)-4-(t-butoxycarbonylamino)piperidine (7.77 g) in ethanol (30 ml) is added a 30% solution of hydrochloric acid in ethanol (15 ml) under ice-cooling, and the mixture is stirred at room temperature for 5 hours. The solvent is evaporated under reduced pressure, and the residue is dissolved in water. The solution is basified with potassium carbonate and extracted with chloroform. The extract is washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent is evaporated under reduced pressure to give the desired compound (6.04 g) as an oily product.

1. temperaturecooling
2. customThe solvent is evaporated under reduced pressure
3. dissolutionthe residue is dissolved in water
4. extractionextracted with chloroform
5. washThe extract is washed with a saturated aqueous sodium chloride solution
6. dry with materialdried over anhydrous magnesium sulfate
7. customthe solvent is evaporated under reduced pressure