Hydrochloric Acid → HCID 13711660, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-ethyl-1-(4′-methoxybenzyl)-2,5-dioxo-4,4-dimethylimidazolidine (3.86 g, 14.0 mmol) in methoxybenzene (100 mL) was treated with alumiun trichloride (5.5 g, 42 mmol), stirred at 75° C. for 30 minute, then poured the reaction into HCl solution (10%) and partitioned between ethyl acetate and brine. The organic layer was dried, filtered, and concentrated. Purification by recrystalization with ethyl acetate provided 2.1 g (13.5 mmol, 96%) of title compound as white solid.

Provenance & Evidence