Hydrochloric Acid → HCID 13711660, compound

HRID 1597414Notes

Reaction equation

HRID 1597414 reaction equation
[CH2:1]([N:3]1[C:7]([CH3:9])([CH3:8])[C:6](=[O:10])[N:5](CC2C=CC(OC)=CC=2)[C:4]1=[O:20])[CH3:2].Cl>COC1C=CC=CC=1>[CH2:1]([N:3]1[C:7]([CH3:8])([CH3:9])[C:6](=[O:10])[NH:5][C:4]1=[O:20])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21700079HCID 21700079, compound

Product 1

HCID 13711660HCID 13711660, compoundYield 96.4%

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Conditions

Temperature
75 °C

Procedure

A solution of 3-ethyl-1-(4′-methoxybenzyl)-2,5-dioxo-4,4-dimethylimidazolidine (3.86 g, 14.0 mmol) in methoxybenzene (100 mL) was treated with alumiun trichloride (5.5 g, 42 mmol), stirred at 75° C. for 30 minute, then poured the reaction into HCl solution (10%) and partitioned between ethyl acetate and brine. The organic layer was dried, filtered, and concentrated. Purification by recrystalization with ethyl acetate provided 2.1 g (13.5 mmol, 96%) of title compound as white solid.

Workup

  1. additionpoured
  2. custompartitioned between ethyl acetate and brine
  3. customThe organic layer was dried
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customPurification
  7. customby recrystalization with ethyl acetate

Sources & evidence

ORD record
ord-c475a89dde3149dd8c292a027858044d
Source dataset
uspto-grants-2001_09
Patent number
US06294573B1

Reaction notes

Loading…