HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Methoxybenzoyl)cyclohexanone → 3-(4-Hydroxyphenyl)-2-(2-(4-methoxybenzoyl)-phenylamino)-propionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Methoxybenzoyl)cyclohexanone | HCID 244418 | — |
| Reactant | H-Tyr(Bzl)-OMe.HCl | HCID 12616037 | — |
| Product | 3-(4-Hydroxyphenyl)-2-(2-(4-methoxybenzoyl)-phenylamino)-propionic acid methyl ester | HCID 54539013 | 28.5% |
Reaction Steps
The title compound (2.31 g) was prepared from 4.64 g (20 mmol) of 2-(4-methoxybenzoyl)-cyclohexanone (Howard, A. S. et. al. Tetrahedron Lett. 1979, (15), 1339-40) and 6.43 g (20 mmol) of O-benzyl-L-tyrosine methyl ester hydrochloride as a yellow solid as described for Intermediate 161: low resolution MS (Cl) m/e 406 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294580B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-b9a3cdfe379a4afebbbdcd554be799e2 |
| Source note | uspto-grants-2001_09 |