反应详情

A mixture of 1-[4-(methylsulfonyl)phenyl]-3-methylpentane-1,4-dione (110 mg, 0.41 mmol), 4-bromoaniline (71 mg, 0.41 mmol), and p-toluenesulfonic acid (10 mg) in toluene (3 mL) was heated at reflux temperature using Dean-Stark apparatus. After cooling down, volatiles were removed by evaporation. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate/hexane (1/3) to give the subtitle compound (110 mg, 67% yield).

1. temperaturewas heated
2. temperatureat reflux temperature
3. temperatureAfter cooling down
4. customvolatiles were removed by evaporation
5. customThe residue was purified by flash chromatography on silica gel eluting with ethyl acetate/hexane (1/3)