Benzonitrile, 4-bromo- → HCID 178426638, compound

HRID 1597592Notes

Reaction equation

HRID 1597592 reaction equation
BrC1C=CC(C#N)=CC=1C.BrC1C=CC(C#N)=CC=1.[Br:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[N:28]([C:37]3[CH:42]=[CH:41][C:40]([S:43]([CH3:46])(=[O:45])=[O:44])=[C:39]([F:47])[CH:38]=3)CC(O)(C(F)(F)F)[N:31]=2)=[CH:23][C:22]=1[CH3:48]>>[F:47][C:39]1[CH:38]=[C:37]([NH:28][C:27]([C:24]2[CH:25]=[CH:26][C:21]([Br:20])=[C:22]([CH3:48])[CH:23]=2)=[NH:31])[CH:42]=[CH:41][C:40]=1[S:43]([CH3:46])(=[O:45])=[O:44]

Participants

4

Reactant 3

HCID 12162Benzonitrile, 4-bromo-HCID 27374944-Bromo-3-methylbenzonitrileHCID 22316937HCID 22316937, compound

Product 1

HCID 178426638HCID 178426638, compound

Procedure

The subtitle compound was prepared according to the procedure of Example 153 (step 1) using 4-bromo-3-methylbenzonitrile, instead of 4-bromobenzonitrile. 2-(4-Bromo-3-methylphenyl)-1-[3-fluoro-4-(methylsulfonyl)phenyl]-4-hydroxy-4-trifluoromethyl-4,5-dihydro-1H-imidazole. (step 2)

Sources & evidence

ORD record
ord-ccce6bfc15e8438f875a6eaf1fea49f4
Source dataset
uspto-grants-2001_09
Patent number
US06294558B1

Reaction notes

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