HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(1,2,3,4-Tetrahydro-1,8-naphthyridin-7-yl)butanoyl-glycyl-beta-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(1,2,3,4-Tetrahydro-1,8-naphthyridin-7-yl)butanoyl-glycyl-beta-alanine t-butyl ester | HCID 21699802 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(1,2,3,4-Tetrahydro-1,8-naphthyridin-7-yl)butanoyl-glycyl-beta-alanine | HCID 21699778 | — |
Reaction Steps
Ester 19-9 (69 mg, 0.17 mmol) was dissolved in 1 mL CH2Cl2 at 0° C., 1 mL TFA was added, and the reaction was warmed to ambient temperature for 6 hr. After concentrating and azeotroping with toluene, flash chromatography (silica, 7:20:1:1 EtOAc/EtOH/H2O/NH4OH) provided 19-10 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06294549B1 |
| Source dataset | uspto-grants-2001_09 |
| ORD ID | ord-f36972228eff4725857d6f409bf52ee5 |
| Source note | uspto-grants-2001_09 |