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HRID1597641

反应详情

EQUATION

反应方程式

HRID 1597641 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)CCNC(=O)CNC(=O)CCCc1ccc2c(n1)NCCC2
HCID21699802

未命名化合物

PRODUCTS

生成物

1
结构：O=C(O)CCNC(=O)CNC(=O)CCCc1ccc2c(n1)NCCC2
HCID21699778

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Ester 19-9 (69 mg, 0.17 mmol) was dissolved in 1 mL CH2Cl2 at 0° C., 1 mL TFA was added, and the reaction was warmed to ambient temperature for 6 hr. After concentrating and azeotroping with toluene, flash chromatography (silica, 7:20:1:1 EtOAc/EtOH/H2O/NH4OH) provided 19-10 as a white solid.

WORKUP

后处理

  1. concentrationAfter concentrating
  2. customazeotroping with toluene, flash chromatography (silica, 7:20:1:1 EtOAc/EtOH/H2O/NH4OH)