HCID 86757458, compound → HCID 44461391, compound

HRID 1597652Notes

Reaction equation

HRID 1597652 reaction equation
C([O:3][C:4](=[O:37])[CH2:5][C@@H:6]([C:27]1[CH:28]=[N:29][C:30]2[C:35]([CH:36]=1)=[CH:34][CH:33]=[CH:32][CH:31]=2)[NH:7][C:8](=[O:26])[CH2:9][NH:10][C:11](=[O:25])[CH2:12][CH2:13][CH2:14][C:15]1[N:24]=[C:23]2[C:18]([CH2:19][CH2:20][CH2:21][NH:22]2)=[CH:17][CH:16]=1)C>Cl>[NH:22]1[C:23]2[C:18](=[CH:17][CH:16]=[C:15]([CH2:14][CH2:13][CH2:12][C:11]([NH:10][CH2:9][C:8]([NH:7][C@H:6]([C:27]3[CH:28]=[N:29][C:30]4[C:35]([CH:36]=3)=[CH:34][CH:33]=[CH:32][CH:31]=4)[CH2:5][C:4]([OH:37])=[O:3])=[O:26])=[O:25])[N:24]=2)[CH2:19][CH2:20][CH2:21]1

Participants

3

Reactant 1

HCID 86757458HCID 86757458, compound

Product 1

HCID 44461391HCID 44461391, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
50 °C

Procedure

Ester 25-6 was dissolved in 5 mL 6N HCl and warmed to 50° C. for 1.5 h then concentrated and the residue chromatographed on silica (75% EtOH. NH3/EtOAc) to afford 25-7.

Workup

  1. concentrationthen concentrated
  2. customthe residue chromatographed on silica (75% EtOH. NH3/EtOAc)
  3. customto afford 25-7

Sources & evidence

ORD record
ord-bb6bc45d3b9a49fb96fd18a59a1ccd83
Source dataset
uspto-grants-2001_09
Patent number
US06294549B1

Reaction notes

Loading…