Lithium Hydroxide → HCID 18932600, compound

HRID 1597765Notes

Reaction equation

HRID 1597765 reaction equation
C([O:3][C:4](=[O:29])[CH2:5][C:6](=[O:28])[C:7](=[O:27])[CH:8]([NH:16][C:17]([O:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)C.[OH-].[Li+]>O1CCOCC1.O>[O:28]=[C:6]([C:7](=[O:27])[CH:8]([NH:16][C:17]([O:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:18])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:5][C:4]([OH:29])=[O:3]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 67642579HCID 67642579, compound

Product 1

HCID 18932600HCID 18932600, compound

Reagents, catalysts & solvents 1

HCID 218864351,4-Dioxane--water (1/1)Solvent

Procedure

To a solution of 3,4-dioxo-5-[((phenylmethoxy)carbonyl)amino]-6-phenylhexanoic acid ethyl ester (400 mg, 1.0 mmol) in dioxane/H2O (10:1), lithium hydroxide (72 mg, 3.0 mmol) is added. The mixture is stirred for 3 h, the solvents are removed in vacuo and the crude product is used without purification.

Workup

  1. customthe solvents are removed in vacuo
  2. customthe crude product is used without purification

Sources & evidence

ORD record
ord-d3c3281cd1ca40e8b8acdf6c5a5f33bc
Source dataset
uspto-grants-1998_04
Patent number
US05736520

Reaction notes

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