反应详情

0.33 ml of triethylamine were added to a solution of 384.4 mg of 2-(1-hydroxyethyl)-benzothiazole [prepared as described in step (b) above] in 4 ml of methylene chloride cooled in an ice-water bath, and then 0.18 ml of methanesulfonyl chloride were added thereto. The temperature of the resulting mixture was elevated to room temperature, and the mixture was then stirred for 2 hours. At the end of this time, a saturated aqueous sodium chloride solution was added to the reaction mixture and the resulting mixture was then extracted with methylene chloride. The resulting extract was washed with water and dried over anhydrous sodium sulfate. The solvent was then removed by evaporation under reduced pressure to given 519.4 mg (yield 94.3%) of the title compound as an oil.

1. temperaturecooled in an ice-water bath
2. customwas elevated to room temperature
3. extractionthe resulting mixture was then extracted with methylene chloride
4. extractionThe resulting extract
5. washwas washed with water
6. dry with materialdried over anhydrous sodium sulfate
7. customThe solvent was then removed by evaporation under reduced pressure