Ethanol → 2-(6-Methyl-1H-indol-3-yl)ethan-1-amine

HRID 1597915Notes

Reaction equation

HRID 1597915 reaction equation
[CH3:1][C:2]1[C:10](Br)=[C:9]2[C:5]([C:6]([CH2:12][CH2:13][NH2:14])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.C(O)C>C(N(CC)CC)C>[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH2:12][CH2:13][NH2:14])=[CH:7][NH:8]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 15274383HCID 15274383, compound

Product 1

HCID 1900062-(6-Methyl-1H-indol-3-yl)ethan-1-amine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A sample of 6-methyl-7-bromo-1H-indole-3-ethanamine was contacted with Pd/C H2 in the presence of ethanol and triethylamine. The resulting material was evaporated and partitioned between base/CHCl3. The organic phase was dried, concentrated, and dried. The resulting material was taken up into methanol and added to ethereal HCl. The resulting material was washed and vacuum dried.

Workup

  1. customThe resulting material was evaporated
  2. custompartitioned between base/CHCl3
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. customdried
  6. additionadded to ethereal HCl
  7. washThe resulting material was washed
  8. customvacuum dried

Sources & evidence

ORD record
ord-cf5ab7a645444cfd928f3ee88ae6d89c
Source dataset
uspto-grants-1998_04
Patent number
US05736544

Reaction notes

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