HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6,7-Dimethoxy-4-(6-methyl-2,3-dihydro-indol-1-yl)-quinazoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 6-methyl-2,3-dihydro-1H-indole | HCID 12203330 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6,7-Dimethoxy-4-(6-methyl-2,3-dihydro-indol-1-yl)-quinazoline hydrochloride | HCID 18932770 | 88% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1, this product was prepared in 88% yield from 6-methyl-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. The HCl salt was generated from the purified free base according to the procedure given in Example 2 (M.P. 231°-232° C.; LC-MS: 322 (MH+); anal. RP18-HPLC RT: 4.32 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-53f92ebbe2ce4a12bb9cd23597d509a2 |
| Source note | uspto-grants-1998_04 |