Hydrochloric Acid → 6,7-Dimethoxy-4-(6-methyl-2,3-dihydro-indol-1-yl)-quinazoline hydrochloride

HRID 1597928Notes

Reaction equation

HRID 1597928 reaction equation
[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][CH:3]=1.[Cl:11][C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1.Cl>CC(O)C>[ClH:11].[CH3:23][O:22][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][C:18]=1[O:24][CH3:25])[N:15]=[CH:14][N:13]=[C:12]2[N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([CH3:1])[CH:10]=2)[CH2:6][CH2:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 122033306-methyl-2,3-dihydro-1H-indole

Product 1

HCID 189327706,7-Dimethoxy-4-(6-methyl-2,3-dihydro-indol-1-yl)-quinazoline hydrochlorideYield 88%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 88% yield from 6-methyl-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. The HCl salt was generated from the purified free base according to the procedure given in Example 2 (M.P. 231°-232° C.; LC-MS: 322 (MH+); anal. RP18-HPLC RT: 4.32 min.).

Sources & evidence

ORD record
ord-53f92ebbe2ce4a12bb9cd23597d509a2
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

Loading…