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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1597929Generated: October 25, 2026

4-Methylindoline → 6,7-Dimethoxy-4-(4-methyl-2,3-dihydro-indol-1-yl)-quinazoline

https://huagongshe.com/reaction/1597929

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethylindolineHCID 583703—
Reactant4-Chloro-6,7-dimethoxyquinazolineHCID 2769364—
SolventIsopropanolHCID 3776—
Product6,7-Dimethoxy-4-(4-methyl-2,3-dihydro-indol-1-yl)-quinazolineHCID 1893279994%

Reaction Steps

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 94% yield from 4-methyl-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 174°-175° C.; LC-MS: 322 (MH+); anal. RP18-HPLC RT: 4.85 min.).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05736534
Source datasetuspto-grants-1998_04
ORD IDord-2f60dc0806f4460ab0297b10e7ff175f
Source noteuspto-grants-1998_04