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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1597931Generated: November 1, 2026

4-Chloro-6,7-dimethoxyquinazoline → HCID 18932842, compound

https://huagongshe.com/reaction/1597931

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Chloro-6,7-dimethoxyquinazolineHCID 2769364—
Reactant5-FluoroindolineHCID 2774463—
SolventIsopropanolHCID 3776—
ProductHCID 18932842HCID 1893284281%

Reaction Steps

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 81% yield from 5-fluoro-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq)in i-PrOH. (M.P. 190°-191° C.; LC-MS: 326 (MH+); anal. RP18-HPLC RT: 4.40 min.).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05736534
Source datasetuspto-grants-1998_04
ORD IDord-b0308b5eb75e42d6984e10da6483c05f
Source noteuspto-grants-1998_04