4-Chloro-6,7-dimethoxyquinazoline → HCID 18932842, compound

HRID 1597931Notes

Reaction equation

HRID 1597931 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH2:6][CH2:5]2.Cl[C:12]1[C:21]2[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=2)[N:15]=[CH:14][N:13]=1>CC(O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([C:12]1[C:21]3[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=3)[N:15]=[CH:14][N:13]=1)[CH2:6][CH2:5]2

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 27744635-Fluoroindoline

Product 1

HCID 18932842HCID 18932842, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 81% yield from 5-fluoro-indoline (1.1 eq.) and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq)in i-PrOH. (M.P. 190°-191° C.; LC-MS: 326 (MH+); anal. RP18-HPLC RT: 4.40 min.).

Sources & evidence

ORD record
ord-b0308b5eb75e42d6984e10da6483c05f
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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