4-Chloro-6,7-dimethoxyquinazoline → HCID 18932746, compound

HRID 1597945Notes

Reaction equation

HRID 1597945 reaction equation
[C:1]1([C:7]2[CH:15]=[C:14]3[C:10]([CH2:11][CH2:12][NH:13]3)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:17]1[C:26]2[C:21](=[CH:22][C:23]([O:29][CH3:30])=[C:24]([O:27][CH3:28])[CH:25]=2)[N:20]=[CH:19][N:18]=1>CC(O)C>[CH3:28][O:27][C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][C:23]=1[O:29][CH3:30])[N:20]=[CH:19][N:18]=[C:17]2[N:13]1[C:14]2[C:10](=[CH:9][CH:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:15]=2)[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 18932726HCID 18932726, compound

Product 1

HCID 18932746HCID 18932746, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 61% yield from 6-phenyl-indoline (1.1 eq.), and 4-chloro-6,7- dimethoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 175°-177° C.; GC-MS: 383 (M+); anal. RP18-HPLC RT: 6.03min.).

Sources & evidence

ORD record
ord-b88e0970e5034a70b334ebedaca81ae7
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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