4-Chloro-6,7-dimethoxyquinazoline → HCID 18932886, compound

HRID 1597948Notes

Reaction equation

HRID 1597948 reaction equation
[CH2:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH2:8][CH2:9][NH:10]2)=[CH:6][CH:5]=1)[CH2:2][CH3:3].Cl[C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[CH:16][N:15]=1>CC(O)C>[CH3:25][O:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[O:26][CH3:27])[N:17]=[CH:16][N:15]=[C:14]2[N:10]1[C:11]2[C:7](=[CH:6][CH:5]=[C:4]([CH2:1][CH2:2][CH3:3])[CH:12]=2)[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 18932801HCID 18932801, compound

Product 1

HCID 18932886HCID 18932886, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 1, this product was prepared in 43% yield from 6-propyl-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in i-PrOH.(M.P. 140°-141° C.; LC-MS: 350 (MH+); anal. RP18-HPLC RT: 5.73 min.).

Sources & evidence

ORD record
ord-7ff67b8657e74480b6ca21990a200d9f
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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