HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6,7-dimethoxyquinazoline → 4-(6-Chloro-5-nitro-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 6-chloro-5-nitro-2,3-dihydro-1H-indole | HCID 18932902 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-(6-Chloro-5-nitro-2,3-dihydro-indol-1-yl)-6,7-dimethoxy-quinazoline | HCID 18932742 | 24% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 47 this product was prepared in 24% yield from 6-chloro-5-nitro-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in N-methyl-pyrrolidinone. (M.P. 276°-278° C.; LC-MS: 387 (MH+); anal. RP18-HPLC RT: 4.48 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-b766cbcd1e4242f0a17841214724231a |
| Source note | uspto-grants-1998_04 |