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HRID1597955

反应详情

EQUATION

反应方程式

HRID 1597955 的结构方程式

REACTANTS

反应物

2
结构：COc1cc2ncnc(Cl)c2cc1OC
HCID2769364

4-Chloro-6,7-dimethoxyquinazoline

C10H9ClN2O2

结构：O=[N+]([O-])c1cc2c(cc1Cl)NCC2
HCID18932902

未命名化合物

PRODUCTS

生成物

1
结构：COc1cc2ncnc(N3CCc4cc([N+](=O)[O-])c(Cl)cc43)c2cc1OC
HCID18932742

未命名化合物

收率 24%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

Utilizing a procedure analogous to that described in Example 47 this product was prepared in 24% yield from 6-chloro-5-nitro-indoline (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in N-methyl-pyrrolidinone. (M.P. 276°-278° C.; LC-MS: 387 (MH+); anal. RP18-HPLC RT: 4.48 min.).