HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(6-Bromo-7-methyl-2,3-dihydro-indol-1-yl)-7-methoxy-quinazoline hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-Bromo-2,3-dihydro-7-methyl-1H-indole | HCID 18473297 | — |
| Reactant | 4-Chloro-7-methoxy-quinazoline | HCID 18925078 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(6-Bromo-7-methyl-2,3-dihydro-indol-1-yl)-7-methoxy-quinazoline hydrochloride salt | HCID 18932728 | 49% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1 (with conversion to the HCl salt as outlined for Example 2), this product was prepared in 49% yield from 6-bromo-7-methyl-indoline (1.1 eq.), and 4-chloro-7-methoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 200°-205° C. (dec); LC-MS: 370, 372 (MH+); anal. RP18-HPLC RT: 5.76 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-82885fb2a605436b8124064bdc9c70f1 |
| Source note | uspto-grants-1998_04 |