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HRID1597957

反应详情

EQUATION

反应方程式

HRID 1597957 反应方程式

REACTANTS

反应物

3
Hydrochloric Acid 分子结构式
HCID313

Hydrochloric Acid

ClH

6-Bromo-2,3-dihydro-7-methyl-1H-indole 分子结构式
HCID18473297

6-Bromo-2,3-dihydro-7-methyl-1H-indole

C9H10BrN

4-Chloro-7-methoxyquinazoline 分子结构式
HCID18925078

4-Chloro-7-methoxyquinazoline

C9H7ClN2O

PRODUCTS

产物

1
HCID 18932728 分子结构式
HCID18932728

未命名化合物

收率 49%

AUXILIARIES

试剂、催化剂与溶剂

1
Isopropanol 分子结构式
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

Utilizing a procedure analogous to that described in Example 1 (with conversion to the HCl salt as outlined for Example 2), this product was prepared in 49% yield from 6-bromo-7-methyl-indoline (1.1 eq.), and 4-chloro-7-methoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. 200°-205° C. (dec); LC-MS: 370, 372 (MH+); anal. RP18-HPLC RT: 5.76 min.).