HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 18932847, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-Chloro-2,3-dihydro-1h-indole | HCID 258567 | — |
| Reactant | 4-Chloro-7-methoxy-quinazoline | HCID 18925078 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 18932847 | HCID 18932847 | 82% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 1 (with conversion to the HCl salt as outlined for Example 2), this product was prepared in 82% yield from 6-chloro-indoline (1.1 eq.), and 4-chloro-7-methoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. of free-base: 140°-141° C.; For HCl salt: M.P. 232°-233° C.; LC-MS: 312 (MH+); anal. RP18-HPLC RT: 5.68 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-dd7c418301764293a3ae1908a6df935c |
| Source note | uspto-grants-1998_04 |