Hydrochloric Acid → HCID 18932847, compound

HRID 1597960Notes

Reaction equation

HRID 1597960 reaction equation
Cl.[Cl:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][NH:9]2)=[CH:5][CH:4]=1.Cl[C:13]1[C:22]2[C:17](=[CH:18][C:19]([O:23][CH3:24])=[CH:20][CH:21]=2)[N:16]=[CH:15][N:14]=1>CC(O)C>[ClH:2].[Cl:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][N:9]2[C:13]2[C:22]3[C:17](=[CH:18][C:19]([O:23][CH3:24])=[CH:20][CH:21]=3)[N:16]=[CH:15][N:14]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 2585676-Chloro-2,3-dihydro-1h-indoleHCID 189250784-Chloro-7-methoxy-quinazoline

Product 1

HCID 18932847HCID 18932847, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 1 (with conversion to the HCl salt as outlined for Example 2), this product was prepared in 82% yield from 6-chloro-indoline (1.1 eq.), and 4-chloro-7-methoxy-quinazoline (1.0 eq) in i-PrOH. (M.P. of free-base: 140°-141° C.; For HCl salt: M.P. 232°-233° C.; LC-MS: 312 (MH+); anal. RP18-HPLC RT: 5.68 min.).

Sources & evidence

ORD record
ord-dd7c418301764293a3ae1908a6df935c
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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