HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6,7-dimethoxyquinazoline → HCID 18932722, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6,7-dimethoxyquinazoline | HCID 2769364 | — |
| Reactant | 8-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine | HCID 16244474 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 18932722 | HCID 18932722 | 58% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 47, this product was prepared in 58% yield from 8-bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in N-methyl-pyrrolidinone. (M.P. 209°-217° C.; LC-MS: 414, 416 (MH+); anal. RP18-HPLC RT: 5.47 min.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05736534 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-7d9d1acf2d0f4a76808d60e70e7f5e29 |
| Source note | uspto-grants-1998_04 |