4-Chloro-6,7-dimethoxyquinazoline → HCID 18932722, compound

HRID 1597971Notes

Reaction equation

HRID 1597971 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][CH2:9][CH2:8][NH:7][C:6]=2[CH:12]=1.Cl[C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[CH:16][N:15]=1>CN1CCCC1=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][CH2:9][CH2:8][N:7]([C:14]3[C:23]4[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=4)[N:17]=[CH:16][N:15]=3)[C:6]=2[CH:12]=1

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 162444748-Bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine

Product 1

HCID 18932722HCID 18932722, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Utilizing a procedure analogous to that described in Example 47, this product was prepared in 58% yield from 8-bromo-2,3,4,5-tetrahydro-1H-benzo[b]azepine (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in N-methyl-pyrrolidinone. (M.P. 209°-217° C.; LC-MS: 414, 416 (MH+); anal. RP18-HPLC RT: 5.47 min.).

Sources & evidence

ORD record
ord-7d9d1acf2d0f4a76808d60e70e7f5e29
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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