4-Chloro-6,7-dimethoxyquinazoline → HCID 18932841, compound

HRID 1597972Notes

Reaction equation

HRID 1597972 reaction equation
[NH:1]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.Cl[C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[CH:16][N:15]=1>CN1CCCC1=O>[CH3:25][O:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[O:26][CH3:27])[N:17]=[CH:16][N:15]=[C:14]2[N:1]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 5324240HCID 5324240, compound

Product 1

HCID 18932841HCID 18932841, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Utilizing a procedure analogous to that described in Example 47, this product was prepared in 67% yield from 1,2,3,4,5,6-hexahydro-benzo[b]azocine (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in N-methyl-pyrrolidinone. (M.P. 204°-207° C.; GC-MS: 349 (M+); anal. RP18-HPLC RT: 5.25 min.).

Sources & evidence

ORD record
ord-68c269a9fd3e44c38899aa940ec48fa1
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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