反应详情

4-Chloro-7-nitroquinazoline (11.22 g, 53.5 mmol) was slurried into 35 ml isopropanol, treated with 6-chloroindoline (8.25 g, 53.7 mmol), refluxed for three hours, then cooled slowly to room temperature. Product was filtered and air dried overnight to afford bright yellow powder; 13.18 g (68%): M.P. 230° C. (dec); LC-MS: 327 (MH+), 329 ((M+2)H+); Calc. C16H11ClN4O2.HCl: C,52.91; H,3.3; N,15.43; Cl,19.52; Found: C,52.77; H,3.61; N,14.78; Cl,19.62.

1. temperaturerefluxed for three hours
2. filtrationProduct was filtered
3. customair dried overnight
4. customto afford bright yellow powder