Hydrochloric Acid → HCID 18932794, compound

HRID 1597990Notes

Reaction equation

HRID 1597990 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([NH:21]C=O)[CH:19]=3)[N:14]=[CH:13][N:12]=2)=[CH:4][CH:3]=1.Cl.C(OCC)C>CO>[ClH:1].[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([NH2:21])[CH:19]=3)[N:14]=[CH:13][N:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 18932851HCID 18932851, compound

Product 1

HCID 18932794HCID 18932794, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

N-[4-(6-Chloro-2,3-dihydro-indol-1-yl)-quinazolin-6-yl]-formamide (1.0055 g, 3.10 mmol) was slurried into 20 mL methanol, treated with 20 mL 1N HCl in methanol, and stirred at room temperature for one hour. Dilution to 125 mL with diethyl ether afforded yellow solid, 0.8430 g (82%; another 0.089 g obtained from subsequent cooling of mother liquor): M.P. 289°-290° C. (dec); LC-MS: 297 (MH+), 299 ((M+2)H+).

Workup

  1. customanother 0.089 g obtained
  2. temperaturefrom subsequent cooling of mother liquor): M.P. 289°-290° C. (dec)

Sources & evidence

ORD record
ord-b526f2f638c9478db08e60c73e3e6be2
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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