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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1597997Generated: November 1, 2026

Hydrochloric Acid → HCID 18932901, compound

https://huagongshe.com/reaction/1597997

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant4-Chloro-6,7-dimethoxyquinazolineHCID 2769364—
ReactantHCID 18382812HCID 18382812—
SolventDimethylformamideHCID 6228—
ProductHCID 18932901HCID 1893290167%

Reaction Steps

Utilizing a procedure analogous to that described in Example 24 (with conversion to its HCl salt using a procedure analogous to that described in Example 2), this product was prepared in 67% yield from 1,2,3,5-tetrahydro-pyrrolo[2,3-f]indole (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in DMF. (M.P. 245°-252° C.; LC-MS: 347 (MH+); RP18-HPLC RT: 3.67 min)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05736534
Source datasetuspto-grants-1998_04
ORD IDord-99cfc49a364e4ecbb3f06267f0cee957
Source noteuspto-grants-1998_04