Hydrochloric Acid → HCID 18932901, compound

HRID 1597997Notes

Reaction equation

HRID 1597997 reaction equation
Cl.[NH:2]1[C:6]2=[CH:7][C:8]3[CH:9]=[CH:10][NH:11][C:12]=3[CH:13]=[C:5]2[CH2:4][CH2:3]1.Cl[C:15]1[C:24]2[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][N:16]=1>CN(C=O)C>[CH3:26][O:25][C:22]1[CH:23]=[C:24]2[C:19](=[CH:20][C:21]=1[O:27][CH3:28])[N:18]=[CH:17][N:16]=[C:15]2[N:11]1[C:12]2=[CH:13][C:5]3[CH:4]=[CH:3][NH:2][C:6]=3[CH:7]=[C:8]2[CH2:9][CH2:10]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 18382812HCID 18382812, compound

Product 1

HCID 18932901HCID 18932901, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Utilizing a procedure analogous to that described in Example 24 (with conversion to its HCl salt using a procedure analogous to that described in Example 2), this product was prepared in 67% yield from 1,2,3,5-tetrahydro-pyrrolo[2,3-f]indole (1.1 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in DMF. (M.P. 245°-252° C.; LC-MS: 347 (MH+); RP18-HPLC RT: 3.67 min)

Sources & evidence

ORD record
ord-99cfc49a364e4ecbb3f06267f0cee957
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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