4-Chloro-6,7-dimethoxyquinazoline → HCID 18932882, compound

HRID 1597998Notes

Reaction equation

HRID 1597998 reaction equation
[NH:1]1[C:5]2=[CH:6][C:7]3[CH2:8][CH2:9][NH:10][C:11]=3[CH:12]=[C:4]2[CH2:3][CH2:2]1.Cl[C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[N:17]=[CH:16][N:15]=1>CN(C=O)C>[CH3:25][O:24][C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][C:20]=1[O:26][CH3:27])[N:17]=[CH:16][N:15]=[C:14]2[N:1]1[C:5]2=[CH:6][C:7]3[CH2:8][CH2:9][NH:10][C:11]=3[CH:12]=[C:4]2[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 27693644-Chloro-6,7-dimethoxyquinazolineHCID 21888003HCID 21888003, compound

Product 1

HCID 18932882HCID 18932882, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Utilizing a procedure analogous to that described in Example 24, this product was prepared in 65% yield from 1,2,3,5,6,7-hexahydro-pyrrolo[2,3-f]indole (1.7 eq.), and 4-chloro-6,7-dimethoxy-quinazoline (1.0 eq) in DMF. (LC-MS: 349 (MH+); RP18-HPLC RT: 3.51 min)

Sources & evidence

ORD record
ord-292a351cc4224ce29f2ecd4138ba6e95
Source dataset
uspto-grants-1998_04
Patent number
US05736534

Reaction notes

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